Cellular Repair & Recovery
KPV
Lys-Pro-Val tripeptide
KPV (Lys-Pro-Val, α-MSH 11-13)
Research context
KPV represents the three C-terminal residues of α-melanocyte-stimulating hormone. Research focuses on NF-κB pathway modulation in epithelial cell lines and on transport via the PepT1 oligopeptide transporter, with cytokine transcript quantification in intestinal epithelial models.
Common assays: NF-κB reporter assay · Cytokine transcript quantification · PepT1 transport
Specification
| Designation | Lys-Pro-Val tripeptide |
|---|---|
| Full name | KPV (Lys-Pro-Val, α-MSH 11-13) |
| Sequence | Lys-Pro-Val |
| CAS number | 67247-12-5 |
| Molecular formula | C16H30N4O4 |
| Molecular weight | 342.44 g/mol |
| Formats | 10 mL Vial · 15 mL Advanced Liquid Peptide Spray |
| Solubility | Sterile water, bacteriostatic water |
| Storage | Lyophilised: −20 °C, desiccated. Reconstituted: 2–8 °C. |
| Current lot | KPV10VCS0126 → |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al.PepT1-mediated tripeptide KPV uptake reduces intestinal inflammationGastroenterology · 2008 Find on PubMed ↗
- Brzoska T, Luger TA, Maaser C, et al.Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivoEndocrine Reviews · 2008 Find on PubMed ↗
Common questions
What is KPV derived from?
The final three residues (lysine, proline, valine) of α-melanocyte-stimulating hormone, a 13-residue endogenous peptide.
What pathway does the KPV literature focus on?
Predominantly NF-κB signalling, with pro-inflammatory cytokine transcript levels as the usual measured endpoint in epithelial models.
Components, blends and pathway
Related compounds
KLOW
KLOW
A prepared four-component blend combining repair-signalling and cytokine-pathway compounds.
GHK-Cu / KPV
Peptide blend
A prepared blend combining a copper tripeptide with the α-MSH C-terminal fragment.
BPC-157 / KPV
Wolverine Oral
A prepared capsule blend combining BPC-157 with the α-MSH C-terminal tripeptide.
Thymosin Alpha-1 / KPV
Peptide blend
A prepared blend combining a thymic peptide with the α-MSH C-terminal tripeptide.