Metabolic Signaling
5-Amino-1MQ
5-Amino-1MQ
5-Amino-1-methylquinolinium
Research context
This quinolinium compound has been characterised as a membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide using S-adenosylmethionine as methyl donor. Research examines intracellular nicotinamide and SAM pool dynamics with downstream NAD⁺ measurement in adipocyte and myocyte models.
Common assays: NNMT enzyme inhibition (IC₅₀) · SAM/SAH ratio · Adipocyte lipolysis quantification
Specification
| Designation | 5-Amino-1MQ |
|---|---|
| Full name | 5-Amino-1-methylquinolinium |
| CAS number | 54-96-6 |
| Molecular formula | C10H11N2+ |
| Molecular weight | 159.21 g/mol |
| Formats | 10 mL Vial · Capsules — 30 count |
| Solubility | Water, DMSO |
| Storage | Sealed, room temperature, desiccated |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Neelakantan H, Vance V, Wetzel MD, et al.Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in miceBiochemical Pharmacology · 2018 Find on PubMed ↗
- Kannt A, Rajagopal S, Kadnur SV, et al.A small molecule inhibitor of nicotinamide N-methyltransferase for the treatment of metabolic disordersScientific Reports · 2018 Find on PubMed ↗
Common questions
What enzyme does 5-Amino-1MQ target?
Nicotinamide N-methyltransferase. Published characterisation focuses on membrane permeability and selectivity relative to other methyltransferases.
Why is NNMT inhibition studied alongside NAD⁺ precursors?
NNMT methylates nicotinamide, diverting it from the salvage pathway. Inhibition is investigated as a mechanism for conserving the existing nicotinamide pool rather than supplementing it.
Same pathway
Related compounds
GLP-1
GLP-1 receptor agonist
A long-acting glucagon-like peptide-1 receptor agonist studied in incretin signalling research.
GLP-2 Dual Agonist
Dual GIP/GLP-1 receptor agonist
A synthetic dual agonist at both GIP and GLP-1 receptors, studied in comparative incretin signalling.
GLP-3 Triple Agonist
Triple GLP-1/GIP/glucagon receptor agonist
A synthetic triple agonist at GLP-1, GIP and glucagon receptors, studied in multi-receptor incretin research.