Metabolic Signaling
GLP-3 Triple Agonist
Triple GLP-1/GIP/glucagon receptor agonist
Triple GLP-1 / GIP / Glucagon Receptor Agonist
Research context
This compound is engineered for agonist activity at three receptors simultaneously — GLP-1, GIP, and glucagon. Research characterises relative potency at each receptor and the contribution of glucagon receptor engagement to energy expenditure endpoints in preclinical models.
Common assays: Triple receptor binding panel · cAMP accumulation per receptor · Indirect calorimetry
Specification
| Designation | Triple GLP-1/GIP/glucagon receptor agonist |
|---|---|
| Full name | Triple GLP-1 / GIP / Glucagon Receptor Agonist |
| Sequence | Synthetic 39-residue peptide with Aib substitutions and C20 diacid conjugation |
| CAS number | 2381089-83-2 |
| Molecular formula | C221H342N46O68 |
| Molecular weight | 4731.32 g/mol |
| Formats | 10 mL Vial · 15 mL Nasal Spray · 15 mL Oral Spray |
| Solubility | Bacteriostatic water, sterile water |
| Storage | Lyophilised: 2–8 °C, protected from light. Reconstituted: 2–8 °C. |
| Current lot | RET10VAS0526 → |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Coskun T, Urva S, Roell WC, et al.LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: from discovery to clinical proof of conceptCell Metabolism · 2022 Find on PubMed ↗
Common questions
Which three receptors does this compound engage?
The glucagon-like peptide-1 receptor, the glucose-dependent insulinotropic polypeptide receptor, and the glucagon receptor.
Why is glucagon receptor activity of research interest?
Glucagon receptor engagement is studied for its association with energy expenditure endpoints, which distinguishes triple agonists from dual GIP/GLP-1 compounds in preclinical comparison.
Same pathway
Related compounds
GLP-1
GLP-1 receptor agonist
A long-acting glucagon-like peptide-1 receptor agonist studied in incretin signalling research.
GLP-2 Dual Agonist
Dual GIP/GLP-1 receptor agonist
A synthetic dual agonist at both GIP and GLP-1 receptors, studied in comparative incretin signalling.
GLP-3 Triple / GLP-1 Blend
Dual agonist blend
A prepared blend combining a triple receptor agonist and a GLP-1 receptor agonist in a single metered format.