Metabolic Signaling
AOD-9604
HGH Fragment 176-191
AOD-9604 (HGH Fragment 176-191)
Research context
AOD-9604 corresponds to residues 176–191 of human growth hormone with an added N-terminal tyrosine. Research examines lipolytic activity in adipocyte preparations independent of the growth-promoting activity associated with the full-length hormone.
Common assays: Adipocyte lipolysis quantification · Glycerol release · Receptor binding characterisation
Specification
| Designation | HGH Fragment 176-191 |
|---|---|
| Full name | AOD-9604 (HGH Fragment 176-191) |
| Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe |
| CAS number | 221231-10-3 |
| Molecular formula | C78H123N23O23S2 |
| Molecular weight | 1815.08 g/mol |
| Formats | 10 mL Vial |
| Solubility | Bacteriostatic water, sterile water |
| Storage | Lyophilised: −20 °C. Reconstituted: 2–8 °C. |
| Current lot | AOD10VAS0426 → |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Heffernan M, Summers RJ, Thorburn A, et al.The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta-3 AR knock-out miceEndocrinology · 2001 Find on PubMed ↗
Common questions
How does AOD-9604 differ from full-length growth hormone?
It comprises only residues 176–191 plus an added tyrosine, and lacks the regions associated with growth-promoting and insulin-antagonistic activity in published characterisation.
Same pathway
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Dual GIP/GLP-1 receptor agonist
A synthetic dual agonist at both GIP and GLP-1 receptors, studied in comparative incretin signalling.
GLP-3 Triple Agonist
Triple GLP-1/GIP/glucagon receptor agonist
A synthetic triple agonist at GLP-1, GIP and glucagon receptors, studied in multi-receptor incretin research.
