Cellular Repair & Recovery
BPC-157
Body Protection Compound-157
Body Protection Compound-157
Research context
BPC-157 corresponds to a partial sequence of body protection compound isolated from human gastric juice. The literature examines fibroblast migration assays measuring cell outgrowth rates, and endothelial models measuring VEGFR2 expression and nitric oxide synthase pathway activity. Additional work characterises stability in gastric conditions relative to peptides of comparable length.
Common assays: Scratch-migration assay · Endothelial tube formation · VEGFR2 transcript quantification · Tendon explant outgrowth
Specification
| Designation | Body Protection Compound-157 |
|---|---|
| Full name | Body Protection Compound-157 |
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
| CAS number | 137525-51-0 |
| Molecular formula | C62H98N16O22 |
| Molecular weight | 1419.53 g/mol |
| Formats | 10 mL Vial · 15 mL Nasal Spray · 15 mL Oral Spray |
| Solubility | Bacteriostatic water, sterile water, dilute acetic acid |
| Storage | Lyophilised: −20 °C, protected from light. Reconstituted: 2–8 °C. |
| Current lot | BPC10VBG0326 → |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Sikirić P, Seiwerth S, Rucman R, et al.Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tractCurrent Pharmaceutical Design · 2011 Find on PubMed ↗
- Chang CH, Tsai WC, Lin MS, et al.The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migrationJournal of Applied Physiology · 2011 Find on PubMed ↗
- Hsieh MJ, Liu HT, Wang CN, et al.Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulationJournal of Molecular Medicine · 2017 Find on PubMed ↗
Common questions
What is the amino acid sequence of BPC-157?
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val — fifteen residues, hence the classification as a pentadecapeptide.
How is BPC-157 purity verified?
RP-HPLC at 214 nm for purity, LC-MS for identity against 1419.53 g/mol. Peptide content by nitrogen determination is reported separately, since net vial weight includes acetate counterion and residual water.
How should BPC-157 be stored?
Lyophilised at −20 °C protected from light; refrigerated at 2–8 °C once reconstituted. Lot-specific stability data appears on the certificate.
Same pathway
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