Cellular Repair & Recovery
TB-500
Thymosin beta-4 fragment
TB-500 (Thymosin Beta-4 fragment)
Research context
TB-500 corresponds to the active region of thymosin beta-4, a 43-residue actin-sequestering protein. Laboratory investigation centres on G-actin binding, cytoskeletal reorganisation, and endothelial cell migration, with published work in corneal and cardiac tissue models measuring migration distance and capillary density.
Common assays: G-actin binding · Endothelial migration · Capillary density quantification
Specification
| Designation | Thymosin beta-4 fragment |
|---|---|
| Full name | TB-500 (Thymosin Beta-4 fragment) |
| Sequence | Actin-binding domain fragment of thymosin beta-4 |
| CAS number | 885340-08-9 |
| Molecular formula | C212H350N56O78S |
| Molecular weight | 4963.44 g/mol |
| Formats | 10 mL Vial · 15 mL Nasal Spray · 15 mL Oral Spray |
| Solubility | Bacteriostatic water, sterile water |
| Storage | Lyophilised: −20 °C, desiccated. Reconstituted: 2–8 °C. |
| Current lot | TB10VCS0126 → |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Goldstein AL, Hannappel E, Kleinman HK.Thymosin β4: actin-sequestering protein moonlights to repair injured tissuesTrends in Molecular Medicine · 2005 Find on PubMed ↗
- Malinda KM, Sidhu GS, Mani H, et al.Thymosin β4 accelerates wound healingJournal of Investigative Dermatology · 1999 Find on PubMed ↗
Common questions
How does TB-500 relate to thymosin beta-4?
TB-500 corresponds to the actin-binding region of the full 43-residue protein rather than the complete molecule. Much of the published activity of Tβ4 in migration assays has been attributed to this region.
Same pathway
Related compounds
BPC-157
Body Protection Compound-157
A synthetic pentadecapeptide derived from a gastric juice sequence, studied in migration and angiogenesis models.
BPC-157 / TB-500
Peptide blend
A prepared blend of the two most extensively studied compounds in the repair signalling literature.
KLOW
KLOW
A prepared four-component blend combining repair-signalling and cytokine-pathway compounds.