Growth Factors
Sermorelin
GHRH analog
Sermorelin (GHRH(1-29)-NH₂)
Research context
Sermorelin corresponds to the first 29 residues of endogenous GHRH with a C-terminal amide, the shortest sequence reported to retain full receptor activity. Research examines GHRH receptor binding, cAMP accumulation, and growth hormone release in pituitary cell preparations, often as the unmodified reference against stabilised analogues.
Common assays: GHRH receptor binding · cAMP accumulation · Pituitary GH secretion
Specification
| Designation | GHRH analog |
|---|---|
| Full name | Sermorelin (GHRH(1-29)-NH₂) |
| Sequence | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂ |
| CAS number | 86168-78-7 |
| Molecular formula | C149H246N44O42S |
| Molecular weight | 3357.88 g/mol |
| Formats | 10 mL Vial |
| Solubility | Bacteriostatic water, sterile water |
| Storage | Lyophilised: 2–8 °C, protected from light. Reconstituted: 2–8 °C. |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Walker RF.Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?Clinical Interventions in Aging · 2006 Find on PubMed ↗
Common questions
How does sermorelin relate to CJC-1295 and tesamorelin?
All three target the GHRH receptor. Sermorelin is the unmodified 1-29 fragment; CJC-1295 is the same fragment with four internal substitutions for enzymatic stability; tesamorelin is the full 44-residue sequence with an N-terminal acyl group.
Why is the 1-29 fragment used rather than full-length GHRH?
Published structure-activity work found the N-terminal 29 residues sufficient for receptor activity, giving a shorter sequence that is simpler to synthesise and characterise.
Components, blends and pathway
Related compounds
CJC-1295
GHRH analog
A tetrasubstituted analogue of growth hormone-releasing hormone (1-29), studied in pituitary secretion research.
CJC-1295 / Ipamorelin
GH Blend
A prepared blend pairing a GHRH analogue with a selective ghrelin receptor secretagogue.
Tesamorelin
GHRH analog
A stabilised 44-residue GHRH analogue carrying an N-terminal hexenoyl modification.
Tesamorelin / Ipamorelin
GH Blend
A prepared blend pairing a full-length GHRH analogue with a selective ghrelin receptor secretagogue.