Vitality
PT-141
Bremelanotide
Bremelanotide (PT-141)
Research context
PT-141 is a cyclic analogue derived from the α-MSH scaffold, characterised as an agonist at melanocortin receptors with reported activity at MC3R and MC4R subtypes. Research examines receptor subtype selectivity and cAMP accumulation in receptor-expressing cell lines.
Common assays: MC1R–MC5R selectivity panel · cAMP accumulation · Receptor binding affinity
Specification
| Designation | Bremelanotide |
|---|---|
| Full name | Bremelanotide (PT-141) |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| CAS number | 189691-06-3 |
| Molecular formula | C50H68N14O10 |
| Molecular weight | 1025.16 g/mol |
| Formats | 10 mL Vial · 15 mL Advanced Liquid Peptide Spray |
| Solubility | Sterile water, bacteriostatic water |
| Storage | Lyophilised: −20 °C, protected from light. Reconstituted: 2–8 °C. |
| Current lot | PT10VAS0126 → |
PT-141 COA: certificates of analysis by lot
3 lots of PT-141 have a published certificate of analysis from AxisPharm, LLC, an independent laboratory. Each certificate reports the laboratory's results for that lot.
| Lot | Format | Purity (HPLC-UV) | Reported |
|---|---|---|---|
| PT10VAS0126 | 10 mg Vial | >99.7% | 2026-02-20 |
| PT10N1125 | 10 mg Spray | >99.0% | 2025-11-24 |
| PT10V1125 | 10 mg Vial | >99% | 2025-11-03 |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Molinoff PB, Shadiack AM, Earle D, et al.PT-141: a melanocortin agonist for the treatment of sexual dysfunctionAnnals of the New York Academy of Sciences · 2003 Find on PubMed ↗
Common questions
How does PT-141 relate to Melanotan II?
Both derive from the α-MSH scaffold. PT-141 is a metabolite of Melanotan II lacking the C-terminal amide, and published characterisation reports a different receptor selectivity profile as a result.
What does the cyclic structure contribute?
The lactam bridge constrains conformation, which published structure-activity work associates with improved receptor selectivity and metabolic stability relative to linear analogues.
Where can I see the PT-141 certificate of analysis?
Every published PT-141 lot has its own certificate page on this site, listed under "PT-141 COA" above. There are 3 published lots; the most recent, lot PT10VAS0126, was reported on 2026-02-20 at >99.7% purity by HPLC-UV. The certificates are issued by AxisPharm, LLC, an independent laboratory.
Components, blends and pathway
Related compounds
PT-141 / Oxytocin
Peptide blend
A prepared blend combining a melanocortin receptor agonist with oxytocin.
PT-141 / Oxytocin / Tesamorelin
Peptide blend
A prepared three-component blend spanning melanocortin, oxytocin, and GHRH receptor ligands.
Melanotan II
Melanotan-II
A cyclic α-MSH analogue studied as a non-selective melanocortin receptor agonist.
Kisspeptin
KISS1-derived peptide
A decapeptide fragment of the KISS1 gene product, studied in GnRH neuron signalling.