Vitality
PT-141
Bremelanotide
Bremelanotide (PT-141)
Research context
PT-141 is a cyclic analogue derived from the α-MSH scaffold, characterised as an agonist at melanocortin receptors with reported activity at MC3R and MC4R subtypes. Research examines receptor subtype selectivity and cAMP accumulation in receptor-expressing cell lines.
Common assays: MC1R–MC5R selectivity panel · cAMP accumulation · Receptor binding affinity
Specification
| Designation | Bremelanotide |
|---|---|
| Full name | Bremelanotide (PT-141) |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| CAS number | 189691-06-3 |
| Molecular formula | C50H68N14O10 |
| Molecular weight | 1025.16 g/mol |
| Formats | 10 mL Vial · 15 mL Nasal Spray · 15 mL Oral Spray |
| Solubility | Sterile water, bacteriostatic water |
| Storage | Lyophilised: −20 °C, protected from light. Reconstituted: 2–8 °C. |
| Current lot | PT10VAS0126 → |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Molinoff PB, Shadiack AM, Earle D, et al.PT-141: a melanocortin agonist for the treatment of sexual dysfunctionAnnals of the New York Academy of Sciences · 2003 Find on PubMed ↗
Common questions
How does PT-141 relate to Melanotan II?
Both derive from the α-MSH scaffold. PT-141 is a metabolite of Melanotan II lacking the C-terminal amide, and published characterisation reports a different receptor selectivity profile as a result.
What does the cyclic structure contribute?
The lactam bridge constrains conformation, which published structure-activity work associates with improved receptor selectivity and metabolic stability relative to linear analogues.
Same pathway
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