Vitality
Kisspeptin
KISS1-derived peptide
Kisspeptin-10 (KISS1-derived decapeptide)
Research context
Kisspeptin-10 is the C-terminal decapeptide of the KISS1 gene product and the minimum sequence retaining full activity at the KISS1R (GPR54) receptor. Research examines GnRH neuron activation, gonadotropin release in pituitary preparations, and receptor binding.
Common assays: KISS1R binding · GnRH neuron electrophysiology · LH release in pituitary preparations
Specification
| Designation | KISS1-derived peptide |
|---|---|
| Full name | Kisspeptin-10 (KISS1-derived decapeptide) |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ |
| CAS number | 374675-21-5 |
| Molecular formula | C63H83N17O14 |
| Molecular weight | 1302.45 g/mol |
| Formats | 10 mL Vial |
| Solubility | Sterile water, bacteriostatic water |
| Storage | Lyophilised: −20 °C, desiccated. Reconstituted: 2–8 °C. |
| Regulatory status | Not an approved drug. Listed in FDA 503A Category 2 as of October 2026; the advisory committee voted against adding it to the 503A bulks list in 2024. 2026 status by compound → |
| Current lot | KIS5VCS0526 → |
Kisspeptin COA: certificates of analysis by lot
One lot of Kisspeptin has a published certificate of analysis from AxisPharm, LLC, an independent laboratory. Each certificate reports the laboratory's results for that lot.
| Lot | Format | Purity (HPLC-UV) | Reported |
|---|---|---|---|
| KIS5VCS0526 | 5 mg Vial | >99.2% | 2026-05-21 |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Kotani M, Detheux M, Vandenbogaerde A, et al.The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54Journal of Biological Chemistry · 2001 Find on PubMed ↗
Common questions
Why is the 10-residue fragment used rather than full-length kisspeptin?
Kisspeptin-10 is the shortest fragment retaining full KISS1R activity in published characterisation, making it the standard research form.
What receptor does kisspeptin act at?
KISS1R, also designated GPR54 — a G protein-coupled receptor expressed on GnRH neurons.
Where can I see the Kisspeptin certificate of analysis?
Every published Kisspeptin lot has its own certificate page on this site, listed under "Kisspeptin COA" above. There is one published lot; the most recent, lot KIS5VCS0526, was reported on 2026-05-21 at >99.2% purity by HPLC-UV. The certificates are issued by AxisPharm, LLC, an independent laboratory.
Components, blends and pathway
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