Vitality
Kisspeptin
KISS1-derived peptide
Kisspeptin-10 (KISS1-derived decapeptide)
Research context
Kisspeptin-10 is the C-terminal decapeptide of the KISS1 gene product and the minimum sequence retaining full activity at the KISS1R (GPR54) receptor. Research examines GnRH neuron activation, gonadotropin release in pituitary preparations, and receptor binding.
Common assays: KISS1R binding · GnRH neuron electrophysiology · LH release in pituitary preparations
Specification
| Designation | KISS1-derived peptide |
|---|---|
| Full name | Kisspeptin-10 (KISS1-derived decapeptide) |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ |
| CAS number | 374675-21-5 |
| Molecular formula | C63H83N17O14 |
| Molecular weight | 1302.45 g/mol |
| Formats | 10 mL Vial |
| Solubility | Sterile water, bacteriostatic water |
| Storage | Lyophilised: −20 °C, desiccated. Reconstituted: 2–8 °C. |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Kotani M, Detheux M, Vandenbogaerde A, et al.The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54Journal of Biological Chemistry · 2001 Find on PubMed ↗
Common questions
Why is the 10-residue fragment used rather than full-length kisspeptin?
Kisspeptin-10 is the shortest fragment retaining full KISS1R activity in published characterisation, making it the standard research form.
What receptor does kisspeptin act at?
KISS1R, also designated GPR54 — a G protein-coupled receptor expressed on GnRH neurons.
Same pathway
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