Cellular Repair & Recovery
Thymosin Alpha-1
Thymalfasin
Thymosin Alpha-1 (Thymalfasin)
Research context
Thymosin alpha-1 is an acetylated 28-residue peptide first characterised from thymosin fraction 5. Research examines Toll-like receptor signalling, dendritic cell maturation markers, and T-cell subset distribution in cell culture and animal models.
Common assays: TLR9/TLR2 reporter assays · Dendritic cell maturation markers · T-cell subset flow cytometry
Specification
| Designation | Thymalfasin |
|---|---|
| Full name | Thymosin Alpha-1 (Thymalfasin) |
| Sequence | Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn |
| CAS number | 62304-98-7 |
| Molecular formula | C129H215N33O55 |
| Molecular weight | 3108.30 g/mol |
| Formats | 10 mL Vial · 15 mL Nasal Spray · 15 mL Oral Spray |
| Solubility | Sterile water, bacteriostatic water |
| Storage | Lyophilised: −20 °C, desiccated. Reconstituted: 2–8 °C. |
| Current lot | TA20N1125 → |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Goldstein AL, Goldstein AL.From lab to bedside: emerging clinical applications of thymosin alpha 1Expert Opinion on Biological Therapy · 2009 Find on PubMed ↗
- Romani L, Bistoni F, Gaziano R, et al.Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through Toll-like receptor signalingBlood · 2004 Find on PubMed ↗
Common questions
Why is Thymosin Alpha-1 N-terminally acetylated?
The native peptide is acetylated in vivo, and the acetyl group is retained in synthetic preparations to match the characterised form. Acetylation state is confirmed by tandem MS on each lot.
How is a 28-residue peptide verified for purity?
HPLC-UV for purity and LC-MS for mass confirmation. For peptides of this length, peptide content by nitrogen analysis is also reported, since net weight includes counterions and residual water.
Same pathway
Related compounds
BPC-157
Body Protection Compound-157
A synthetic pentadecapeptide derived from a gastric juice sequence, studied in migration and angiogenesis models.
TB-500
Thymosin beta-4 fragment
A synthetic fragment corresponding to the actin-binding domain of thymosin beta-4.
BPC-157 / TB-500
Peptide blend
A prepared blend of the two most extensively studied compounds in the repair signalling literature.