Cellular Repair & Recovery
VIP
Vasoactive intestinal peptide
Vasoactive Intestinal Peptide
Research context
VIP is a 28-residue amidated neuropeptide belonging to the secretin/glucagon superfamily. Research examines binding at the VPAC1 and VPAC2 receptor subtypes, cAMP accumulation, and cytokine profile measurement in immune cell preparations.
Common assays: VPAC1/VPAC2 binding · cAMP accumulation · Cytokine profiling
Specification
| Designation | Vasoactive intestinal peptide |
|---|---|
| Full name | Vasoactive Intestinal Peptide |
| Sequence | His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂ |
| CAS number | 37221-79-7 |
| Molecular formula | C147H238N44O42S |
| Molecular weight | 3325.80 g/mol |
| Formats | 10 mL Vial |
| Solubility | Sterile water, bacteriostatic water |
| Storage | Lyophilised: −20 °C, desiccated. Reconstituted: 2–8 °C, use promptly. |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Delgado M, Ganea D.Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functionsAmino Acids · 2013 Find on PubMed ↗
Common questions
What receptors does VIP act at?
VPAC1 and VPAC2, both class B G protein-coupled receptors. It also has affinity for the PAC1 receptor, so selectivity panels typically include all three.
Why is prompt use recommended after reconstitution?
VIP contains methionine, which is oxidation-prone, and the C-terminal amide is required for activity. Both argue for short solution storage and aliquoting at first reconstitution.
Same pathway
Related compounds
BPC-157
Body Protection Compound-157
A synthetic pentadecapeptide derived from a gastric juice sequence, studied in migration and angiogenesis models.
TB-500
Thymosin beta-4 fragment
A synthetic fragment corresponding to the actin-binding domain of thymosin beta-4.
BPC-157 / TB-500
Peptide blend
A prepared blend of the two most extensively studied compounds in the repair signalling literature.