Neurotropic & Cognitive
Dihexa
Angiotensin IV analog
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide)
Research context
Dihexa was developed as a metabolically stable analogue in the angiotensin IV series. Published research characterises interaction with the hepatocyte growth factor / c-Met receptor system and measures dendritic spine formation and synaptic density in hippocampal preparations.
Common assays: Dendritic spine quantification · c-Met phosphorylation · Hippocampal slice electrophysiology
Specification
| Designation | Angiotensin IV analog |
|---|---|
| Full name | Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) |
| Sequence | N-hexanoic-Tyr-Ile-NH-(CH₂)₅-CONH₂ |
| CAS number | 1401708-83-5 |
| Molecular formula | C29H46N4O5 |
| Molecular weight | 530.71 g/mol |
| Formats | Capsules — 30 count |
| Solubility | DMSO, ethanol; limited aqueous solubility |
| Storage | Sealed, −20 °C, protected from light |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- McCoy AT, Benoist CC, Wright JW, et al.Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agentsJournal of Pharmacology and Experimental Therapeutics · 2013 Find on PubMed ↗
- Benoist CC, Kawas LH, Zhu M, et al.The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-Met systemJournal of Pharmacology and Experimental Therapeutics · 2014 Find on PubMed ↗
Common questions
What receptor system does the Dihexa literature focus on?
The hepatocyte growth factor / c-Met system, with synaptogenesis endpoints such as dendritic spine density.
Why does Dihexa have limited aqueous solubility?
The hexanoic acid modification that confers metabolic stability also increases lipophilicity. DMSO or ethanol is typically used for stock preparation.
Same pathway
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