Neurotropic & Cognitive
Semax
ACTH(4-10) analog
Semax (ACTH 4-10 analogue)
Research context
Semax comprises the 4-10 fragment of adrenocorticotropic hormone extended at the C-terminus with a proline-glycine-proline sequence conferring resistance to enzymatic degradation. Published research examines BDNF and NGF transcript expression in neural tissue models alongside monoamine measurements.
Common assays: BDNF/TrkB transcript quantification · Neuronal survival assay · Monoamine turnover
Specification
| Designation | ACTH(4-10) analog |
|---|---|
| Full name | Semax (ACTH 4-10 analogue) |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| CAS number | 80714-61-0 |
| Molecular formula | C37H51N9O10S |
| Molecular weight | 813.93 g/mol |
| Formats | 10 mL Vial · 15 mL Nasal Spray · 15 mL Oral Spray |
| Solubility | Sterile water, bacteriostatic water |
| Storage | Lyophilised: −20 °C. Reconstituted: 2–8 °C. |
| Current lot | SEM10V1125 → |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Dolotov OV, Karpenko EA, Inozemtseva LS, et al.Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrainJournal of Neurochemistry · 2006 Find on PubMed ↗
- Ashmarin IP, Nezavibatko VN, Levitskaya NG, et al.Design and investigation of an ACTH(4-10) analog lacking D-amino acids and hydrophobic radicalsNeuroscience Research Communications · 1995 Find on PubMed ↗
Common questions
Why is Semax extended with Pro-Gly-Pro?
The C-terminal PGP extension substantially reduces enzymatic degradation relative to the unmodified ACTH(4-10) fragment, which is what makes the analogue practical for research use.
What endpoints appear most often in the Semax literature?
BDNF and NGF transcript levels, TrkB receptor expression, and monoamine turnover in neural tissue preparations.
Same pathway
Related compounds
Selank
Tuftsin analog heptapeptide
A synthetic tuftsin analogue with a stabilising Pro-Gly-Pro extension, studied in GABAergic signalling.
Semax / Selank
Peptide blend
A prepared blend of two Pro-Gly-Pro stabilised heptapeptides.
DSIP
Delta sleep-inducing peptide
A nonapeptide first isolated from cerebral venous blood, studied in sleep architecture research.