Neurotropic & Cognitive
Selank
Tuftsin analog heptapeptide
Selank (tuftsin analogue heptapeptide)
Research context
Selank is derived from tuftsin, an endogenous immunomodulatory tetrapeptide, with a C-terminal PGP extension conferring degradation resistance. Research examines GABA receptor binding, interleukin transcript profiles, and enkephalinase activity in neural and immune preparations.
Common assays: GABA receptor binding · Interleukin transcript quantification · Enkephalinase activity
Specification
| Designation | Tuftsin analog heptapeptide |
|---|---|
| Full name | Selank (tuftsin analogue heptapeptide) |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| CAS number | 129954-34-3 |
| Molecular formula | C33H57N11O9 |
| Molecular weight | 751.88 g/mol |
| Formats | 10 mL Vial · 15 mL Advanced Liquid Peptide Spray |
| Solubility | Sterile water, bacteriostatic water |
| Storage | Lyophilised: −20 °C. Reconstituted: 2–8 °C. |
| Regulatory status | Not an approved drug. Previously listed in FDA 503A Category 2; its nomination has since been withdrawn. 2026 status by compound → |
| Current lot | SEL10V1125 → |
Selank COA: certificates of analysis by lot
One lot of Selank has a published certificate of analysis from AxisPharm, LLC, an independent laboratory. Each certificate reports the laboratory's results for that lot.
| Lot | Format | Purity (HPLC-UV) | Reported |
|---|---|---|---|
| SEL10V1125 | 10 mg Vial | >99.0% | 2025-11-13 |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Kozlovskii II, Danchev ND.The optimizing action of synthetic peptide Selank on a conditioned active avoidance reflex in ratsNeuroscience and Behavioral Physiology · 2003 Find on PubMed ↗
- Volkova A, Shadrina M, Kolomin T, et al.Selank administration affects the expression of some genes involved in GABAergic neurotransmissionFrontiers in Pharmacology · 2016 Find on PubMed ↗
Common questions
What is Selank derived from?
Tuftsin, a naturally occurring immunomodulatory tetrapeptide (Thr-Lys-Pro-Arg), extended with proline-glycine-proline for stability.
How does Selank compare structurally to Semax?
Both are heptapeptides using the same Pro-Gly-Pro stabilising strategy, but with different parent sequences — Selank from tuftsin, Semax from ACTH(4-10).
Where can I see the Selank certificate of analysis?
Every published Selank lot has its own certificate page on this site, listed under "Selank COA" above. There is one published lot; the most recent, lot SEL10V1125, was reported on 2025-11-13 at >99.0% purity by HPLC-UV. The certificates are issued by AxisPharm, LLC, an independent laboratory.
Components, blends and pathway
Related compounds
Semax / Selank
Peptide blend
A prepared blend of two Pro-Gly-Pro stabilised heptapeptides.
Semax
ACTH(4-10) analog
A synthetic ACTH(4-10) analogue extended with Pro-Gly-Pro, studied in neurotrophic factor expression.
DSIP
Delta sleep-inducing peptide
A nonapeptide first isolated from cerebral venous blood, studied in sleep architecture research.
Dihexa
Angiotensin IV analog
A metabolically stabilised angiotensin IV analogue studied in hepatocyte growth factor / c-Met signalling.