Longevity & Cellular Renewal
Epitalon
Ala-Glu-Asp-Gly tetrapeptide
Epitalon (Ala-Glu-Asp-Gly tetrapeptide)
Research context
Epitalon is a synthetic tetrapeptide derived from work on pineal peptide preparations. The published literature examines telomerase reverse transcriptase expression and telomere length measurement in cultured human fibroblast models, alongside investigation of melatonin-related signalling.
Common assays: TERT expression (qPCR) · Telomere length (TRF/qPCR) · Melatonin quantification
Specification
| Designation | Ala-Glu-Asp-Gly tetrapeptide |
|---|---|
| Full name | Epitalon (Ala-Glu-Asp-Gly tetrapeptide) |
| Sequence | Ala-Glu-Asp-Gly |
| CAS number | 307297-39-8 |
| Molecular formula | C14H22N4O9 |
| Molecular weight | 390.35 g/mol |
| Formats | 10 mL Vial · 15 mL Advanced Liquid Peptide Spray |
| Solubility | Sterile water, bacteriostatic water |
| Storage | Lyophilised: −20 °C, desiccated. Reconstituted: 2–8 °C. |
| Regulatory status | Not an approved drug. Removed from FDA 503A Category 2 in April 2026 and recommended for the 503A bulks list by the advisory committee in July 2026. Since 30 October 2026, an HHS interim policy says the agency will not take enforcement action against licensed 503A compounding of it under set conditions. It has not been added to the bulks list. 2026 status by compound → |
| Current lot | EPI50V1225C → |
Epitalon COA: certificates of analysis by lot
3 lots of Epitalon have a published certificate of analysis from AxisPharm, LLC, an independent laboratory. Each certificate reports the laboratory's results for that lot.
| Lot | Format | Purity (HPLC-UV) | Reported |
|---|---|---|---|
| EPI50V1225C | 50 mg Vial | >99.2% | 2025-12-17 |
| EPI100V1125 | 100 mg Vial | >99.0% | 2025-12-04 |
| EPI100N1125P | 100 mg Spray | >99.0% | 2025-11-24 |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Khavinson VK, Bondarev IE, Butyugov AA.Epithalon peptide induces telomerase activity and telomere elongation in human somatic cellsBulletin of Experimental Biology and Medicine · 2003 Find on PubMed ↗
- Khavinson VK, Popovich IG.Short peptides regulate gene expressionBulletin of Experimental Biology and Medicine · 2020 Find on PubMed ↗
Common questions
What is the difference between Epitalon and Epithalamin?
Epithalamin refers to a peptide preparation extracted from pineal tissue; Epitalon is a defined synthetic tetrapeptide developed from that work. Only the synthetic form has a single defined sequence.
What endpoints appear in the Epitalon literature?
Telomerase reverse transcriptase expression and telomere length measurement, most commonly in cultured human fibroblasts.
Where can I see the Epitalon certificate of analysis?
Every published Epitalon lot has its own certificate page on this site, listed under "Epitalon COA" above. There are 3 published lots; the most recent, lot EPI50V1225C, was reported on 2025-12-17 at >99.2% purity by HPLC-UV. The certificates are issued by AxisPharm, LLC, an independent laboratory.
Components, blends and pathway
Related compounds
Epitalon / Thymulin
Peptide blend
A prepared blend combining a synthetic pineal-derived tetrapeptide with a thymic nonapeptide.
NAD+
Nicotinamide adenine dinucleotide
The central redox cofactor of cellular metabolism and substrate for sirtuins, PARPs, and CD38.
MOTS-C
Mitochondrial-derived peptide
A 16-residue peptide encoded in the mitochondrial genome, studied in AMPK signalling.
SS-31
Elamipretide
A cell-permeable tetrapeptide with affinity for cardiolipin, studied in mitochondrial membrane research.