Longevity & Cellular Renewal
MOTS-C
Mitochondrial-derived peptide
MOTS-c (Mitochondrial ORF of the 12S rRNA type-c)
Research context
MOTS-c is encoded within an open reading frame of the mitochondrial 12S rRNA gene, making it one of a small class of mitochondrially encoded peptides. Research examines AMP-activated protein kinase activation and folate–methionine cycle intermediates, with glucose uptake measured in myocyte culture models.
Common assays: AMPK phosphorylation (Western) · Glucose uptake · Folate cycle metabolomics
Specification
| Designation | Mitochondrial-derived peptide |
|---|---|
| Full name | MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| CAS number | 1627580-64-6 |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174.62 g/mol |
| Formats | 10 mL Vial · 15 mL Nasal Spray · 15 mL Oral Spray |
| Solubility | Sterile water, bacteriostatic water |
| Storage | Lyophilised: −20 °C. Reconstituted: 2–8 °C. |
| Current lot | MOT20VAS0126 → |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Lee C, Zeng J, Drew BG, et al.The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistanceCell Metabolism · 2015 Find on PubMed ↗
- Reynolds JC, Lai RW, Woodhead JST, et al.MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasisNature Communications · 2021 Find on PubMed ↗
Common questions
What makes MOTS-c unusual among peptides?
It is encoded in the mitochondrial genome rather than the nuclear genome — one of a small number of identified mitochondrial-derived peptides.
What signalling pathway dominates the MOTS-c literature?
AMP-activated protein kinase, with associated measurements of folate–methionine cycle intermediates.
Same pathway
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