Longevity & Cellular Renewal
Humanin
Mitochondrial-derived peptide
Humanin (mitochondrial-derived peptide)
Research context
Humanin was identified from mitochondrial DNA and is encoded within the 16S rRNA region. Research examines interaction with a tripartite receptor complex and with Bax, alongside apoptosis endpoints in neuronal and other cell models.
Common assays: Bax interaction · Apoptosis quantification · Receptor complex binding
Specification
| Designation | Mitochondrial-derived peptide |
|---|---|
| Full name | Humanin (mitochondrial-derived peptide) |
| Sequence | Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala |
| CAS number | 330936-69-1 |
| Molecular formula | C122H196N38O32S2 |
| Molecular weight | 2687.20 g/mol |
| Formats | 10 mL Vial |
| Solubility | Sterile water; DMSO for stock preparation |
| Storage | Lyophilised: −20 °C, desiccated. Reconstituted: 2–8 °C. |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Hashimoto Y, Niikura T, Tajima H, et al.A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer disease genes and AbetaProceedings of the National Academy of Sciences · 2001 Find on PubMed ↗
- Lee C, Yen K, Cohen P.Humanin: a harbinger of mitochondrial-derived peptides?Trends in Endocrinology & Metabolism · 2013 Find on PubMed ↗
Common questions
How is humanin related to MOTS-c?
Both are mitochondrial-derived peptides encoded within mitochondrial rRNA genes — humanin in 16S, MOTS-c in 12S. They were among the first identified members of this class.
Same pathway
Related compounds
NAD+
Nicotinamide adenine dinucleotide
The central redox cofactor of cellular metabolism and substrate for sirtuins, PARPs, and CD38.
MOTS-C
Mitochondrial-derived peptide
A 16-residue peptide encoded in the mitochondrial genome, studied in AMPK signalling.
SS-31
Elamipretide
A cell-permeable tetrapeptide with affinity for cardiolipin, studied in mitochondrial membrane research.