Longevity & Cellular Renewal
Methyl B12
Methylcobalamin
Methylcobalamin (Vitamin B12)
Research context
Methylcobalamin is one of two biologically active cobalamin forms and serves as cofactor for methionine synthase in the conversion of homocysteine to methionine. Research applications include one-carbon metabolism studies and methylation cycle work.
Common assays: Cobalamin quantification by HPLC · Methionine synthase kinetics
Specification
| Designation | Methylcobalamin |
|---|---|
| Full name | Methylcobalamin (Vitamin B12) |
| CAS number | 13422-55-4 |
| Molecular formula | C63H91CoN13O14P |
| Molecular weight | 1344.38 g/mol |
| Formats | 10 mL Vial |
| Solubility | Water |
| Storage | Sealed, 2–8 °C, protected from light — photosensitive |
| Regulatory status | Not an approved drug. Listed in FDA 503A Category 1 (under evaluation) as of October 2026. 2026 status by compound → |
| Current lot | MB100VAS0426 → |
Methyl B12 COA: certificates of analysis by lot
One lot of Methyl B12 has a published certificate of analysis from AxisPharm, LLC, an independent laboratory. Each certificate reports the laboratory's results for that lot.
| Lot | Format | Purity (HPLC-UV) | Reported |
|---|---|---|---|
| MB100VAS0426 | 100 mg Vial | 99.2% | 2026-06-15 |
Published literature
Selected peer-reviewed references describing research involving this compound. Listed for reference only; inclusion is not a claim about any outcome.
- Banerjee R, Ragsdale SW.The many faces of vitamin B12: catalysis by cobalamin-dependent enzymesAnnual Review of Biochemistry · 2003 Find on PubMed ↗
Common questions
Why is methylcobalamin light-sensitive?
The cobalt-carbon bond is photolabile. Light exposure cleaves it, converting the compound to hydroxocobalamin — which is why amber containers and light protection are standard.
Where can I see the Methyl B12 certificate of analysis?
Every published Methyl B12 lot has its own certificate page on this site, listed under "Methyl B12 COA" above. There is one published lot; the most recent, lot MB100VAS0426, was reported on 2026-06-15 at 99.2% purity by HPLC-UV. The certificates are issued by AxisPharm, LLC, an independent laboratory.
Components, blends and pathway
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